This compound works best at one very specific dose—too little does nothing, too much hurts—and scientists can predict this pattern very accurately with math.
Scientific Claim
Brosimine B exhibits a biphasic (hormetic) dose-response in avian retinal cells, with maximal cell viability at 10.2 µM and a hormetic zone width of 6.5 µM, as modeled by an inverted U-shaped Gaussian function (R² = 0.984).
Original Statement
“A computational modeling approach using a hormetic (inverted U-shaped) model revealed biologically interpretable parameters, including a peak response at 10.2 µM and a hormetic zone width (σ = 6.5 µM) (R² = 0.984).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The model describes an observed pattern in data; it does not prove causation or biological necessity. The language appropriately reflects association and modeling, not mechanism or universal law.
Evidence from Studies
Supporting (1)
Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection
The study found that a little bit of Brosimine B helps retinal cells survive stress, but too much hurts them — and the best dose was 10.2 µM, which matches exactly what the claim says.