If you give too much of this compound, it starts killing eye cells instead of helping them—typical of many natural substances that have a narrow safe range.
Scientific Claim
Brosimine B is cytotoxic at concentrations above 25 µM in avian retinal cell cultures, reducing viability to below control levels, which aligns with the toxic phase of hormetic dose-response patterns in natural compounds.
Original Statement
“Exposure of the mixed culture to higher concentrations of Brosimine B drastically reduced cell viability: 25.00 μM (0.95 ± 0.15, **p < 0.0001), 50.00 μM (1.72 ± 0.20, *p < 0.0001), and 100.00 μM (2.64 ± 0.18, *p < 0.0001).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Cytotoxicity is observed as an association between concentration and reduced viability; no mechanism is proven. The language appropriately avoids causal claims.
Evidence from Studies
Supporting (0)
Contradicting (1)
Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection
The study found that Brosimine B becomes toxic at just over 10 µM, not 25 µM as the claim says — so the claim’s number is wrong.