This compound only works if you give it at just the right amount—too little or too much doesn’t help, so getting the dose exactly right is super important.

Scientific Claim

The hormetic response of Brosimine B in retinal cells is characterized by a peak stimulation at 10.2 µM and a narrow effective range (σ = 6.5 µM), suggesting that precise dosing is critical for therapeutic application in oxidative stress models.

Original Statement

“The fitted parameters were baseline = 0.715, amplitude = 0.217, x0 (peak concentration) = 10.2 µM, and σ (spread) = 6.5 µM. This model reflects the stimulatory effect of Brosimine B at lower concentrations, peaking around 10 μM, followed by cytotoxic responses at higher doses...”

From study:Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The model describes an observed pattern in data; it does not prove that precise dosing is universally required. 'Suggesting' appropriately reflects the inferential nature of the conclusion.

Evidence from Studies

Supporting (1)

Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Cross-Sectional Study

Animal

The study found that Brosimine B works best at a very specific dose (10.2 µM) and stops working or even harms cells if you use too much or too little, so you have to be super precise when using it as a treatment.

Contradicting (0)

No contradicting evidence found

Source Study

Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Score: 12

DOI: 10.3389/fphar.2025.1558726

Similar Assertions

If you give too much of this compound, it starts killing eye cells instead of helping them—typical of many natural substances that have a narrow safe range.

81%

A natural compound called Brosimine B helps retinal cells survive better at a very specific low dose, but hurts them if you give too much.

80%

This compound can help eye cells survive short-term oxygen loss, but loses its power if the stress lasts too long.

79%

At the right dose, this compound can reduce harmful stress molecules in eye cells—but only if given right after the stress starts, not later.

79%

This compound works best at one very specific dose—too little does nothing, too much hurts—and scientists can predict this pattern very accurately with math.

78%