Cyclocreatine gets into brain-like cells in a lab mainly using a special doorway called the creatine transporter — when scientists block or remove this doorway, less cyclocreatine gets in, suggesting it relies on that path.

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Pro

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Against

Evidence from Studies

Supporting (1)

4

Community contributions welcome

4

Cyclocreatine Transport by SLC6A8, the Creatine Transporter, in HEK293 Cells, a Human Blood-Brain Barrier Model Cell, and CCDSs Patient-Derived Fibroblasts

Cross-Sectional Study

In Vitro

2020 Mar 2

The study shows that cyclocreatine gets into brain-relevant cells using the same gateway as creatine, and when that gateway is blocked or broken, less cyclocreatine gets in—just like the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Cyclocreatine Transport by SLC6A8, the Creatine Transporter, in HEK293 Cells, a Human Blood-Brain Barrier Model Cell, and CCDSs Patient-Derived Fibroblasts

Score: 4

DOI: 10.1007/s11095-020-2779-0

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6

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