How a brain medicine gets inside cells
Cyclocreatine Transport by SLC6A8, the Creatine Transporter, in HEK293 Cells, a Human Blood-Brain Barrier Model Cell, and CCDSs Patient-Derived Fibroblasts
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists wanted to see how a medicine called cyclocreatine gets into brain-related cells. They tested it in lab-grown cells and cells from patients who can't move creatine into their brains.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists wanted to see how a medicine called cyclocreatine gets into brain-related cells. They tested it in lab-grown cells and cells from patients who can't move creatine into their brains.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 54 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Uemura T, Ito S, Masuda T, Shimbo H, Goto T, Osaka H, Wada T, Couraud PO, Ohtsuki S
Related Content
Claims (4)
Cells use a special pump to create a sodium imbalance outside and inside the cell, and that imbalance acts like a battery to help pull creatine into the cell through a specific door called SLC6A8.
Cyclocreatine gets into brain-like cells in a lab mainly using a special doorway called the creatine transporter — when scientists block or remove this doorway, less cyclocreatine gets in, suggesting it relies on that path.
In people with a rare brain disorder caused by a broken creatine transporter, their cells don't take in creatine or a similar molecule called cyclocreatine as well — showing the broken transporter affects both in the same way.
Cyclocreatine gets into kidney cells in a way that looks like it's being actively carried in, not just drifting in on its own—kind of like being carried through a door instead of seeping through a wall.