mechanistic
Analysis v1
Strong Support
In people with a rare brain disorder caused by a broken creatine transporter, their cells don't take in creatine or a similar molecule called cyclocreatine as well — showing the broken transporter affects both in the same way.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Cyclocreatine Transport by SLC6A8, the Creatine Transporter, in HEK293 Cells, a Human Blood-Brain Barrier Model Cell, and CCDSs Patient-Derived Fibroblasts
Cross-Sectional Study
In Vitro
2020 Mar 2The study found that both creatine and cyclocreatine don’t get into cells as well when the transporter is broken, which is exactly what the claim says.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.