Eating a lot of sucralose (an artificial sweetener) over time might make your body less responsive to insulin and change the good bacteria in your gut, which could make it harder for your body to manage blood sugar.

Even though tasting artificial sweetener makes some people’s bodies release insulin, it doesn’t make them feel hungrier or change their blood sugar right after—so the insulin spike doesn’t seem to do anything noticeable yet.

If you're overweight and swap sugary drinks for diet drinks with sucralose for 12 weeks, your waist size and blood sugar levels may go down, and your good cholesterol may go up.

If you're overweight or obese and drink diet soda with sucralose for 12 weeks, your body doesn't absorb it — it just passes through, and doctors couldn't find any trace of it in the blood.

When mice on a fatty diet drank sucralose instead of fructose, they became more sensitive to insulin and gained less weight—but they didn’t do any better than mice that just drank water.

When rats and mice eat sucralose, a common artificial sweetener, their guts get more inflamed, their intestinal lining gets weaker, and the good and bad bacteria in their intestines change — all of which might cause body-wide inflammation.