DunedinPACE detected slowing of aging from calorie restriction better than other DNA-based aging clocks because it tracks how fast the body is deteriorating over time, while the others measure accumulated risk at a single point.
Evidence from Studies
No evidence studies found yet.
What Would Prove This
Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.
Whether DunedinPACE consistently outperforms PhenoAge and GrimAge in detecting changes from lifestyle or pharmacological interventions across diverse human trials.
A systematic review and meta-analysis of all human trials reporting changes in DunedinPACE, PhenoAge, and GrimAge in response to interventions (diet, exercise, drugs), comparing standardized effect sizes and statistical power.
Whether DunedinPACE detects smaller or earlier changes than PhenoAge/GrimAge in response to identical interventions.
A 3-arm RCT of 200 adults comparing the sensitivity of DunedinPACE, PhenoAge, and GrimAge to detect changes from a 12-week low-calorie diet, measuring biomarkers at baseline, 6, 12, and 24 weeks with repeated measures ANOVA.
Whether DunedinPACE changes over time correlate more strongly with physiological decline than PhenoAge or GrimAge in the same individuals.
A longitudinal cohort study of 1,000 adults aged 30–50 with annual DunedinPACE, PhenoAge, GrimAge, and physiological assessments (grip strength, VO2max, cognitive tests) over 10 years, modeling which clock best predicts functional decline.
Whether individuals with early physiological decline show DunedinPACE acceleration before PhenoAge or GrimAge changes occur.
A nested case-control study comparing 150 individuals with early decline in physical function to 150 matched controls, analyzing DunedinPACE, PhenoAge, and GrimAge trajectories from stored samples collected 5–10 years prior to decline.
Whether DunedinPACE correlates more strongly with multi-system physiological function than PhenoAge or GrimAge in the same individuals.
A cross-sectional analysis of 2,000 adults measuring DunedinPACE, PhenoAge, GrimAge, and 15 physiological markers (e.g., lung function, kidney filtration, insulin sensitivity) to compare correlation strengths.