Analysis Version
v1
History
Back to Study: Effect of long-term caloric restriction on DNA met...
quantitative
Analysis v1
Strong Support

Cutting calories for two years doesn’t seem to change certain biological age clocks in healthy adults, even though other signs of aging improved.

59
Pro
0
Against

Evidence from Studies

Supporting (1)

59

Community contributions welcome

59

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

Randomized Controlled Trial
Human
2023 Mar

The study looked at whether eating fewer calories for two years changed certain biological age clocks, and found it didn’t affect the PhenoAge and GrimAge clocks, just like the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

Score: 59
DOI: 10.1038/s43587-022-00357-y

Similar Assertions

If healthy-weight adults eat 25% less food for two years, it might slow down how fast their body ages—based on a special aging test—though not all aging tests showed a change.

53
0
91%

Cutting calories doesn’t seem to slow aging in healthy-weight adults when measured with certain DNA tests, and the effect might depend on which test you use.

53
0
91%

Cutting calories a bit for two years might slow how fast your body ages on a cellular level, according to a study on healthy adults who aren’t overweight.

59
0
88%

A new aging test called DunedinPACE can spot small changes from healthy habits better than older tests, especially after just a couple of years of eating less — making it a better tool for testing anti-aging treatments quickly.

59
0
82%

Cutting calories helps people get healthier, and while a DNA aging test called DunedinPACE shows some of these benefits, it only catches a small part of the full picture.

59
0
80%