Endothelin-1 reduces the ability of insulin to promote glucose uptake into cells by interfering with the cytoskeletal changes that move GLUT4 transporters to the cell surface.
Likely supported
Evidence leans toward this claim being true.
Not medical advice. For informational purposes only. Always consult a healthcare professional.
Endothelin-1 reduces the ability of insulin to promote glucose uptake into cells by interfering with the cytoskeletal changes that move GLUT4 transporters to the cell surface.
See the technical phrasing
Endothelin-1 inhibits insulin-stimulated glucose uptake by disrupting RAC1-mediated cytoskeletal remodeling required for GLUT4 translocation.
Endothelin-1 binds to receptors on the cell surface, triggering a signal that breaks down the internal scaffold made of actin and membrane lipids needed to move glucose transporters to the surface. Without this scaffold, the transporters cannot reach the membrane, so glucose cannot enter the cell even when insulin is present.
What the research says
Supports
2 studies
Study: Endothelin-1 inhibits insulin-stimulated glucose uptake in isolated rat adipocytes.
This study provides evidence supporting the claim.
Contradicts
3 studies
Study: Evidence that endothelin-1 (ET-1) inhibits insulin-stimulated glucose uptake in rat adipocytes mainly through ETA receptors.
This study provides evidence contradicting the claim.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 5 supporting studies