The Study
Evidence that endothelin-1 (ET-1) inhibits insulin-stimulated glucose uptake in rat adipocytes mainly through ETA receptors.
This study looked at fat cells from rats and said something about one protein, but we don’t know how they did the experiment. So we can’t say for sure if it’s true or what it means — it’s just a hint, not proof.
Analysis score
Maximum 58 for a case-control study.
Where the score came from
A chemical called endothelin-1 stops fat cells from taking in sugar when insulin tells them to, and it does this mainly through one specific door (ETA receptor).
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 56 / 100
Quality score
Researchers compare people who have a condition (cases) with similar people who do not (controls), looking back in time for differences in exposure. Useful but more prone to bias.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Not specified
- 2Not specified
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Metabolism: clinical and experimental
Year
1998
Authors
Y. C. Lee, C. Juan, V. Fang, Y. Hsu, S. H. Lin, C. Kwok, L. Ho
Related Content
Claims (2)
Endothelin-1 reduces the ability of insulin to promote glucose uptake into cells by interfering with the cytoskeletal changes that move GLUT4 transporters to the cell surface.
Endothelin-1 reduces the ability of insulin to promote glucose uptake in fat cells from rats by activating ETA receptors.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.