For adults with a genetic cholesterol problem who are already on cholesterol meds, taking a pill called enlicitide every day for 6 months might drastically lower a key heart disease risk protein in their blood.

47

Pro

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Against

Evidence from Studies

Supporting (1)

47

Community contributions welcome

47

Efficacy and Safety of Oral PCSK9 Inhibitor Enlicitide in Adults With Heterozygous Familial Hypercholesterolemia: A Randomized Clinical Trial.

Randomized Controlled Trial

Human

1988 Jun

The study tested the same pill, in the same people, for the same amount of time, and found exactly what the claim says: it greatly lowers a key blood protein linked to heart disease.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Efficacy and Safety of Oral PCSK9 Inhibitor Enlicitide in Adults With Heterozygous Familial Hypercholesterolemia: A Randomized Clinical Trial.

Score: 47

DOI: 10.1001/jama.2025.20620

Similar Assertions

For adults with a genetic cholesterol problem who are already taking cholesterol pills, adding a daily 20 mg pill called enlicitide for 6 months cuts a harmful type of blood fat (lipoprotein(a)) by about a quarter—way more than a dummy pill does.

47

0

94%

For adults with a genetic cholesterol problem and already taking statins, adding a pill called enlicitide every day for 6 months slashed bad cholesterol levels by over half, while a fake pill barely changed anything.

47

0

93%

For people with a genetic cholesterol problem who are already on cholesterol meds, taking a pill called enlicitide every day for a year keeps their bad cholesterol way down — cutting it by more than half — while those not taking it see their levels go up.

47

0

91%

For people with a genetic cholesterol problem who are already on cholesterol pills, taking a new drug called enlicitide every day for 6 months might slash their bad cholesterol way more than just the usual treatment alone.

47

0

85%

A drug called AMG 145 can lower a harmful blood protein linked to heart disease by up to 59% in people with high cholesterol who are already taking statins, and it seems to do more than just lower bad cholesterol.

63

0

75%