A pill that helps lower bad cholesterol even more in people who already take statins
Efficacy and Safety of Oral PCSK9 Inhibitor Enlicitide in Adults With Heterozygous Familial Hypercholesterolemia: A Randomized Clinical Trial.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some people have very high bad cholesterol because of their genes. Even when they take cholesterol pills like statins, their levels stay too high. This study tested a new pill called enlicitide to see if it helps lower cholesterol even more.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 547 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some people have very high bad cholesterol because of their genes. Even when they take cholesterol pills like statins, their levels stay too high. This study tested a new pill called enlicitide to see if it helps lower cholesterol even more.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 547 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
von der Helm D, von der Helm K, Burg G, Braun-Falco O, Deinhardt F
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Claims (6)
For adults with a genetic cholesterol problem who are already on cholesterol meds, taking a pill called enlicitide every day for 6 months might drastically lower a key heart disease risk protein in their blood.
For people with a genetic cholesterol problem who are already on cholesterol pills, taking a new drug called enlicitide every day for 6 months might slash their bad cholesterol way more than just the usual treatment alone.
For people with a genetic cholesterol problem who are already on cholesterol meds, taking a pill called enlicitide every day for a year keeps their bad cholesterol way down — cutting it by more than half — while those not taking it see their levels go up.
For adults with a genetic cholesterol problem and already taking statins, adding a pill called enlicitide every day for 6 months slashed bad cholesterol levels by over half, while a fake pill barely changed anything.
For adults with a genetic cholesterol problem who are already taking cholesterol pills, adding a daily 20 mg pill called enlicitide for 6 months cuts a harmful type of blood fat (lipoprotein(a)) by about a quarter—way more than a dummy pill does.