In eye cells from people with a thyroid eye disease, a lab-made version of a hormone turns on a cellular signal but doesn't trigger the production of a gooey substance that causes swelling — meaning the signal doesn't always lead to the swelling effect.

21

Pro

0

Against

Evidence from Studies

Supporting (1)

21

Community contributions welcome

21

Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways

Cross-Sectional Study

Human

2011 Feb

The study shows that a lab-made hormone (rhTSH) turns on a signal (cAMP) in eye cells from Graves’ disease patients but doesn’t make them produce the problematic substance (hyaluronan), just like the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways

Score: 21

DOI: 10.1089/thy.2010.0123

Similar Assertions

In most people with a thyroid eye problem called Graves' ophthalmopathy, certain immune proteins seem to make eye cells produce a gooey substance, and they do it using backup routes instead of the main one scientists expected.

21

0

80%

When a certain receptor in eye cells gets turned on, it triggers processes that cause the cells to release a gooey substance, leading to eye bulging and swelling in people with thyroid eye disease.

1

0

75%

Autoantibodies from people with Graves' disease can turn on a gooey substance in eye fat cells, which might explain why their eyes bulge out.

21

0

71%

When eye cells from people with a serious eye condition get turned into fat-like cells, they start making more of a certain protein receptor — this might explain why the disease gets worse when fat builds up in the eyes.

21

0

70%