When eye cells from people with a serious eye condition get turned into fat-like cells, they start making more of a certain protein receptor — this might explain why the disease gets worse when fat builds up in the eyes.

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Against

Evidence from Studies

Supporting (1)

21

Community contributions welcome

21

Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways

Cross-Sectional Study

Human

2011 Feb

The study found that when eye cells from Graves’ disease patients turn into fat-like cells, they produce more of a certain receptor linked to the disease, which supports the idea that this change boosts the receptor’s levels.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways

Score: 21

DOI: 10.1089/thy.2010.0123

Similar Assertions

In most people with a thyroid eye problem called Graves' ophthalmopathy, certain immune proteins seem to make eye cells produce a gooey substance, and they do it using backup routes instead of the main one scientists expected.

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In Graves’ disease, certain immune proteins can mistakenly attack eye tissue, causing swelling and bulging eyes.

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In eye cells from people with a thyroid eye disease, a lab-made version of a hormone turns on a cellular signal but doesn't trigger the production of a gooey substance that causes swelling — meaning the signal doesn't always lead to the swelling effect.

21

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