In most people with a thyroid eye problem called Graves' ophthalmopathy, certain immune proteins seem to make eye cells produce a gooey substance, and they do it using backup routes instead of the main one scientists expected.

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Evidence from Studies

Supporting (1)

21

Community contributions welcome

21

Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways

Cross-Sectional Study

Human

2011 Feb

The study shows that in eye cells from Graves’ disease patients, the immune proteins (GD-IgG) cause swelling-related substance (hyaluronan) to be made, even when the usual signal (cAMP) isn’t very active—meaning other signals are likely at work.

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No contradicting evidence found

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Source Study

Thyrotropin Receptor-Stimulating Graves' Disease Immunoglobulins Induce Hyaluronan Synthesis by Differentiated Orbital Fibroblasts from Patients with Graves' Ophthalmopathy Not Only Via Cyclic Adenosine Monophosphate Signaling Pathways

Score: 21

DOI: 10.1089/thy.2010.0123

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