Even though eating trans fats seems bad for your heart, the amount of trans fat found in your blood doesn’t clearly link to heart disease risk in these studies.

Scientific Claim

Circulating levels of trans fatty acids show no significant association with coronary disease risk (RR: 1.05, 95% CI: 0.76–1.44) in biomarker-based observational studies, despite dietary intake showing a clear link.

Original Statement

“Corresponding estimates for circulating fatty acids were ... 1.05 (CI, 0.76 to 1.44) ... for trans fatty acids, respectively.”

From study:Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim correctly reports the non-significant biomarker result and acknowledges the discrepancy with dietary data without overinterpreting.

Evidence from Studies

Supporting (1)

Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis

Systematic Review With Meta-Analysis

Human

2014 Mar 18

Even though eating trans fats is linked to heart disease, measuring trans fats in the blood doesn’t show a clear connection — and this study proves it.

Contradicting (0)

No contradicting evidence found

Source Study

Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis

Score: 42

DOI: 10.7326/m13-1788

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