Analysis Version
v1
History
Back to Study: Association of dietary, circulating, and supplemen...
correlational
Analysis v1
42
Pro
0
Against

People with more omega-3 fats in their blood don’t clearly have lower heart disease risk, even though the numbers hint at a possible benefit.

Scientific Claim

Circulating levels of long-chain omega-3 fatty acids show a non-significant 16% reduction in coronary disease risk (RR: 0.84, 95% CI: 0.63–1.11) in biomarker-based observational studies.

Original Statement

“Corresponding estimates for circulating fatty acids were ... 0.84 (CI, 0.63 to 1.11) ... for long-chain ω-3 polyunsaturated ... respectively.”

From study:Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim accurately reflects the non-significant trend and avoids overstating benefit. The wide CI justifies cautious interpretation.

Evidence from Studies

Supporting (1)

42
42

Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis

Systematic Review With Meta-Analysis
Human
2014 Mar 18

This big study looked at blood levels of omega-3 fats in thousands of people and found that those with higher levels had about 16% lower heart disease risk—but the result wasn’t strong enough to say for sure it wasn’t just chance.

Contradicting (0)

0
No contradicting evidence found

Source Study

Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis

Score: 42
DOI: 10.7326/m13-1788

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