The amount of saturated fat found in your blood doesn’t seem to predict whether you’ll get heart disease, based on blood tests from many people.

Scientific Claim

Circulating levels of saturated fatty acids show no significant association with coronary disease risk (RR: 1.06, 95% CI: 0.86–1.30) in biomarker-based observational studies.

Original Statement

“Corresponding estimates for circulating fatty acids were 1.06 (CI, 0.86 to 1.30) ... for saturated ... respectively.”

From study:Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim correctly uses association language and reports the non-significant CI, consistent with observational biomarker data and avoiding causal inference.

Evidence from Studies

Supporting (1)

Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis

Systematic Review With Meta-Analysis

Human

2014 Mar 18

This big study looked at the amount of saturated fat in people’s blood and found no clear link to heart disease — meaning having more or less didn’t reliably change their risk.

Contradicting (0)

No contradicting evidence found

Source Study

Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis

Score: 42

DOI: 10.7326/m13-1788

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