Older adults with heart disease who took a low dose of a drug called rapamycin every day for 3 months didn’t get less frail, even though the drug changed some aging-related markers in their bodies.

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Evidence from Studies

Supporting (1)

31

Community contributions welcome

31

Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.

Cross-Sectional Study

Human

2016

The study gave older heart patients a low dose of rapamycin for 12 weeks and saw changes in aging-related markers, but their physical frailty didn't get better. This matches the claim that the drug didn't help with frailty even though it changed some biological signs.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.

Score: 31

DOI: 10.14283/JFA.2016.112

Similar Assertions

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Taking a low dose of a drug called rapamycin every day for three months might have increased a protein in the blood linked to healing and inflammation in older people with heart disease — but we’re not sure what that really means for their health.

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71%