What does rapamycin do to aging signs in older hearts?
Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Older people with heart disease took a low dose of a drug called rapamycin for 12 weeks to see if it changed signs of aging in their body.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Older people with heart disease took a low dose of a drug called rapamycin for 12 weeks to see if it changed signs of aging in their body.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 531 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Singh M, Jensen MD, Lerman A, Kushwaha S, Rihal CS, Gersh BJ, Behfar A, Tchkonia T, Thomas RJ, Lennon RJ, Keenan LR, Moore AG, Kirkland JL
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Claims (5)
Taking rapamycin, even in small doses now and then, might increase the chance of getting serious infections like pneumonia in older people because it can weaken the immune system.
Taking a low dose of a drug called rapamycin every day for three months might have increased a protein in the blood linked to healing and inflammation in older people with heart disease — but we’re not sure what that really means for their health.
Older adults with heart disease who took a low dose of a drug called rapamycin every day for 3 months didn’t get less frail, even though the drug changed some aging-related markers in their bodies.
Older adults with heart disease who took a low dose of a drug called rapamycin every day for 12 weeks saw their inflammation levels go down, which might help slow aging-related damage in the body.
Older guys with heart disease who took a low dose of a drug called rapamycin every day for 12 weeks showed signs that their body fat was aging more slowly.