What does rapamycin do to aging signs in older hearts?
Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Frailty did not improve despite reductions in key senescence biomarkers like IL-6 and p16.
Many assume that if a drug reduces biological signs of aging, it should lead to better physical function—this study shows that assumption may be wrong.
Practical Takeaways
Do not take rapamycin for anti-aging purposes outside of clinical supervision, especially if you have heart disease or are older.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Frailty did not improve despite reductions in key senescence biomarkers like IL-6 and p16.
Many assume that if a drug reduces biological signs of aging, it should lead to better physical function—this study shows that assumption may be wrong.
Practical Takeaways
Do not take rapamycin for anti-aging purposes outside of clinical supervision, especially if you have heart disease or are older.
Publication
Journal
The Journal of frailty & aging
Year
2016
Authors
Mandeep Singh, M. Jensen, Amir Lerman, Sudhir S. Kushwaha, C. Rihal, Bernard J. Gersh, A. Behfar, Tamar Tchkonia, Randal Thomas, Ryan J. Lennon, L. Keenan, A. G. Moore, James L Kirkland
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Claims (5)
Taking rapamycin, even in small doses now and then, might increase the chance of getting serious infections like pneumonia in older people because it can weaken the immune system.
Taking a low dose of a drug called rapamycin every day for three months might have increased a protein in the blood linked to healing and inflammation in older people with heart disease — but we’re not sure what that really means for their health.
Older adults with heart disease who took a low dose of a drug called rapamycin every day for 3 months didn’t get less frail, even though the drug changed some aging-related markers in their bodies.
Older adults with heart disease who took a low dose of a drug called rapamycin every day for 12 weeks saw their inflammation levels go down, which might help slow aging-related damage in the body.
Older guys with heart disease who took a low dose of a drug called rapamycin every day for 12 weeks showed signs that their body fat was aging more slowly.