Taking a low dose of a drug called rapamycin every day for three months might have increased a protein in the blood linked to healing and inflammation in older people with heart disease — but we’re not sure what that really means for their health.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.

Cross-Sectional Study

Human

2016

The study gave older adults with heart disease a low dose of rapamycin for 12 weeks and found their MMP-3 levels went up, just like the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.

Score: 31

DOI: 10.14283/JFA.2016.112

Similar Assertions

Older adults with heart disease who took a low dose of a drug called rapamycin every day for 12 weeks saw their inflammation levels go down, which might help slow aging-related damage in the body.

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81%

Older guys with heart disease who took a low dose of a drug called rapamycin every day for 12 weeks showed signs that their body fat was aging more slowly.

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74%

Older adults with heart disease who took a low dose of a drug called rapamycin every day for 3 months didn’t get less frail, even though the drug changed some aging-related markers in their bodies.

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71%