The Claim
Under maximal insulin stimulation (1.0 mU/kg·min), suppression of lipolysis in subcutaneous adipose tissue (22±2% of baseline) is significantly greater than in skeletal muscle (53±4% of baseline), indicating that skeletal muscle retains higher residual lipolytic activity despite greater insulin sensitivity.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When insulin levels are maximally elevated, fat breakdown is more strongly suppressed in fat tissue than in muscle tissue, meaning muscle continues to break down more fat even under strong insulin signaling.
See the scientific wording
During the highest insulin infusion step (1.0 mU/kg·min), lipolysis suppression in subcutaneous adipose tissue (22±2% of baseline) was significantly greater than in skeletal muscle (53±4% of baseline), indicating that despite greater sensitivity, muscle retains higher residual lipolytic activity under maximal insulin stimulation.
When insulin levels are very high, fat cells in the belly stop breaking down fat almost completely, but muscle cells still break down a little bit of fat. This happens because insulin turns off the same enzymes in both tissues, but those enzymes in muscle don’t shut down as fully, so muscle keeps releasing a small amount of fat even when insulin is at its strongest.
What the research says
1 studyEven when insulin is given at its highest dose, fat cells in the belly still stop breaking down fat more completely than muscle cells do — meaning muscle keeps releasing a bit more fat even when insulin is trying to stop it.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.