Back to "Exendin-4 is a 39 amino acid peptide iso..."
Claim
Strong Support
mechanistic
Analysis v3

A substance called Exendin-4 works like a longer-lasting version of a natural hormone in your body that helps control blood sugar, so it might help people with type 2 diabetes manage their glucose...

6
Pro
0
Against

Evidence from Studies

Supporting (1)

6

Community contributions welcome

6

Expression and purification of exendin-4, a GLP-1 receptor agonist, in Escherichia coli.

Cross-Sectional Study
Animal & In Vitro
2005 Jun

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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Source Study

Expression and purification of exendin-4, a GLP-1 receptor agonist, in Escherichia coli.

Score: 6
DOI: 10.1016/j.pep.2004.10.014

Similar Assertions

Blocking the GLP-1 receptor with exendin(9-39) eliminates the improvements in insulin sensitivity and blood glucose control that result from liraglutide treatment in people with obesity and prediabetes, indicating that these effects require GLP-1 receptor activity.

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A chemical from Gila monster spit lasts longer in the body than a natural hormone because it doesn’t break down as quickly, so it keeps working longer to control blood sugar.

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Blocking the GLP-1 receptor with exendin(9-39) eliminates the improvements in insulin sensitivity and blood glucose control caused by liraglutide in people with obesity and prediabetes, indicating that these effects depend on activation of the GLP-1 receptor.

89
0
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