Making diabetes medicine in bacteria
Expression and purification of exendin-4, a GLP-1 receptor agonist, in Escherichia coli.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Practical Takeaways
Biological drugs like exendin-4 may eventually be produced more affordably using bacterial systems like E. coli.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Practical Takeaways
Biological drugs like exendin-4 may eventually be produced more affordably using bacterial systems like E. coli.
Publication
Journal
Protein expression and purification
Year
2005
Authors
Xiaopu Yin, D. Wei, L. Yi, X. Tao, Yushu Ma
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Claims (6)
A chemical from Gila monster spit lasts longer in the body than a natural hormone because it doesn’t break down as quickly, so it keeps working longer to control blood sugar.
Scientists can use bacteria to make a diabetes drug called exendin-4 by inserting the right instructions into the bacteria's machinery using a special tool.
Scientists can fish out a special lab-made protein from bacteria using a kind of molecular magnet, so they can turn it into its final form later.
Scientists can make a useful protein called exendin-4 in bacteria, cut it out cleanly using a special enzyme, and end up with a specific amount of the pure protein from a given amount of bacteria.
A substance called Exendin-4 works like a longer-lasting version of a natural hormone in your body that helps control blood sugar, so it might help people with type 2 diabetes manage their glucose levels better.