What we've found so far suggests that taking GLS along with lifestyle changes may reduce liver enzyme levels more than polyene phosphatidylcholine in adults with nonalcoholic fatty liver disease. Our current analysis is based on a single assertion from the evidence pool, which indicates a potential advantage for GLS [1].
We looked at what the available research shows about GLS—a supplement studied in the context of fatty liver—and how it compares to polyene phosphatidylcholine when both are used alongside diet, exercise, or other lifestyle improvements. The evidence we've reviewed leans toward GLS being more effective at lowering liver enzymes over a 12-week period [1]. Since elevated liver enzymes often reflect liver inflammation or damage, a greater reduction could suggest better liver protection with GLS compared to the other supplement.
However, we only have one assertion to draw from, supported by 63.0 studies, with no studies refuting it [1]. While the number of supporting studies sounds substantial, we don’t have details on the quality, design, or consistency of those studies, so we can’t determine how strong the conclusion should be. Also, we don’t know if the difference in enzyme levels leads to meaningful health improvements, like reduced liver fat or fibrosis.
Our analysis right now is limited. We’re working with a narrow view, and as more data becomes available, our understanding could change. We can’t say how large the effect is, how long it lasts, or whether it applies to all adults with nonalcoholic fatty liver disease.
Practical takeaway: If you're considering supplements alongside lifestyle changes for fatty liver, GLS might have more research backing its effect on liver enzymes than polyene phosphatidylcholine—but we don’t know enough yet to say how much better it is or whether it leads to healthier livers in the long run.
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