The Claim
In adult female mice subjected to 8 weeks of progressive weighted wheel running, both frequent (2 mg/kg, three times weekly) and intermittent (2 mg/kg, once weekly) rapamycin treatment impair glucose tolerance compared to vehicle-treated controls, with intermittent dosing resulting in less severe glucose intolerance than frequent dosing, indicating that dosing frequency modulates the metabolic side effects of rapamycin.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In female mice that exercised with weighted wheels for 8 weeks, taking the drug rapamycin — even just once a week — made their blood sugar control worse, but doing it less often caused fewer problems.
See the scientific wording
In adult female mice undergoing 8 weeks of progressive weighted wheel running, both frequent (2 mg/kg, three times weekly) and intermittent (2 mg/kg, once weekly) rapamycin treatment impair glucose tolerance compared to vehicle-treated mice, though intermittent dosing results in less severe glucose intolerance than frequent dosing, suggesting dosing frequency modulates metabolic side effects.
What the research says
1 studyStudy: Rapamycin Does Not Compromise Exercise‐Induced Muscular Adaptations in Female Mice
The study found that giving rapamycin to female mice that exercised made their blood sugar control worse, especially when given more often. But giving it once a week caused fewer problems than three times a week.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.