In female mice that exercised with weighted wheels for 8 weeks, taking the drug rapamycin — even just once a week — made their blood sugar control worse, but doing it less often caused fewer problems.

In female mice that run with added weight, taking a drug called rapamycin makes it harder for their bodies to handle sugar — but doing it less often doesn't hurt as much, so spacing out doses might help reduce the downside.

Female mice on a weekly rapamycin dose ran more and faster than those on a more frequent dose or no drug, but despite running more, they didn’t lose more fat or get healthier metabolically.

Giving female mice a certain drug (rapamycin) once a week helps them run more on their own compared to giving it more often or not at all.

In female mice that run a lot, taking rapamycin frequently stops them from losing fat — even though exercise usually helps them slim down.

Even when taking rapamycin, female mice still get stronger and fitter from using a weighted exercise wheel — the drug doesn't stop their workout gains.