In female cynomolgus macaques, eating a Mediterranean diet is linked to higher levels of a gut bacterium called Lactobacillus animalis, and higher levels of this bacterium are linked to lower body...
Mechanism
Synthesis from 1 study
Eating more plants helps good gut bacteria grow, which turn a nutrient into a compound that seals the gut lining. This stops harmful substances from leaking into the blood and causing inflammation, which in turn helps the body keep less fat.
Most probable mechanism
When a plant-rich diet is eaten, certain good bacteria in the gut, including Lactobacillus animalis, grow more and turn a nutrient called tryptophan into a compound that strengthens the gut lining. This prevents harmful substances from leaking into the bloodstream, which reduces overall inflammation. Less inflammation helps the body store less fat, leading to lower body fat levels.
Consumption of a plant-rich diet increases the abundance of Lactobacillus animalis and related Lactobacillus species in the gut
Lactobacillus animalis and Clostridium species metabolize dietary tryptophan to produce indole-3-propionate
Indole-3-propionate enhances the integrity of the intestinal barrier, reducing translocation of bacterial lipopolysaccharides into systemic circulation
Reduced systemic exposure to bacterial lipopolysaccharides lowers chronic low-grade inflammation
Lower systemic inflammation is associated with reduced lipid storage and decreased adiposity
Less supported by current evidence, but not ruled out
Lactobacillus animalis may help lower fat storage by influencing how the body processes fats and cholesterol, leading to less fat accumulation.
Lactobacillus animalis abundance is negatively correlated with body fat percentage
Lactobacillus species influence lipid metabolism through modulation of bile acid signaling and cholesterol absorption
Reduced cholesterol absorption and altered lipid partitioning lead to decreased adipose tissue accumulation
A plant-rich diet reduces harmful bacteria that produce toxins and trigger inflammation, which in turn helps the body store less fat.
Mediterranean diet suppresses abundance of Prevotella copri and Ruminococcus champaneliensis, which are linked to inflammation and energy overharvest
Reduced Prevotella copri lowers production of uremic toxins and acyl-carnitines that impair insulin signaling and promote fat storage
Reduced Ruminococcus champaneliensis lowers cortisol elevation and energy harvest from indigestible fibers, reducing fat accumulation
Evidence from Studies
Supporting (1)
Community contributions welcome
Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model
Contradicting (0)
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Gold Standard Evidence Needed
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