Why junk food might hurt your gut and kidneys
Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Monkeys fed a Western diet (like burgers and fries) had more of a gut bug called Prevotella copri, which was linked to signs of early kidney stress. Monkeys on a Mediterranean diet (like veggies and olive oil) had healthier gut bugs and better cholesterol levels.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 518 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Monkeys fed a Western diet (like burgers and fries) had more of a gut bug called Prevotella copri, which was linked to signs of early kidney stress. Monkeys on a Mediterranean diet (like veggies and olive oil) had healthier gut bugs and better cholesterol levels.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 518 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Newman TM, Shively CA, Register TC, Appt SE, Yadav H, Colwell RR, Fanelli B, Dadlani M, Graubics K, Nguyen UT, Ramamoorthy S, Uberseder B, Clear KYJ, Wilson AS, Reeves KD, Chappell MC, Tooze JA, Cook KL
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Claims (7)
In female cynomolgus macaques eating a Western diet, higher levels of the gut bacterium Prevotella copri are linked to increased levels of certain metabolites in urine and blood that are known to appear early in kidney stress, suggesting the gut microbiome may influence kidney function under high-fat diets.
In female cynomolgus macaques, eating a Mediterranean diet is linked to higher levels of a gut bacterium called Lactobacillus animalis, and higher levels of this bacterium are linked to lower body fat, indicating it may reflect metabolic health in the context of a plant-rich diet.
In female cynomolgus macaques, eating a Western diet for over two years is linked to higher levels of the gut bacterium Prevotella copri compared to a Mediterranean diet, and this change correlates with specific metabolic markers such as increased urinary carnitine metabolites and plasma allantoic acid.
In female cynomolgus macaques eating a Western diet, lower levels of the bacterium Prevotella copri are linked to greater diversity in gut microbes and higher levels of Eubacterium siraeum, which in turn are associated with higher levels of HDL cholesterol in the blood.
In female cynomolgus macaques, a Western diet is linked to lower gut microbial diversity than a Mediterranean diet. Within the Western diet group, animals with less Prevotella copri bacteria tend to have higher microbial diversity than those with more of this bacterium, suggesting that diet and bacterial levels together influence the overall microbial community.