Fluid buildup caused by TZDs can still be treated with loop diuretics like furosemide in people with insulin resistance.
Scientific Claim
In 12 insulin-resistant nondiabetic adults, 9 weeks of rosiglitazone (4 mg twice daily) is not associated with impaired response to loop diuretics for fluid retention.
Original Statement
“This study challenges previous findings regarding TZD-related ENaC upregulation and suggests that TZD-induced fluid retention should respond normally to loop diuretics.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The abstract uses causal language ('should respond normally'), but the study design is a cohort study without confirmed RCT details, so causation cannot be established; the claim should use association language.
Evidence from Studies
Supporting (1)
Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study