Fluid buildup caused by TZDs can still be treated with loop diuretics like furosemide in people with insulin resistance.

Evidence Quality Assessment

Claim Status

overstated

Study Design Support

Design cannot support claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The abstract uses causal language ('should respond normally'), but the study design is a cohort study without confirmed RCT details, so causation cannot be established; the claim should use association language.

Evidence from Studies

Supporting (1)

31

Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study

Randomized Controlled Trial

Human

2011 Apr

Contradicting (0)

0

No contradicting evidence found

Source Study

Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study

Score: 31

DOI: 10.1038/clpt.2010.360

Similar Assertions

Rosiglitazone doesn't increase the amount of a specific sodium channel protein in urine of insulin-resistant people.

31

0

84%

Rosiglitazone doesn't change how furosemide works at different doses in people with insulin resistance.

31

0

80%

Taking rosiglitazone doesn't affect how well amiloride (another diuretic) removes salt from the body in insulin-resistant people.

31

0

78%

Taking rosiglitazone for 9 weeks doesn't make the diuretic medicine furosemide less effective at removing salt from the body in people with insulin resistance.

31

0

77%