Does rosiglitazone make water pills less effective?
Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Researchers tested if a diabetes drug called rosiglitazone makes water pills less effective at removing salt and water. They gave 12 people with insulin resistance either the drug or a placebo for 9 weeks. They checked how well the water pills worked. The drug didn't change how the water pills worked.
Surprising Findings
Rosiglitazone didn't reduce furosemide's effectiveness despite previous theories
Earlier research suggested TZDs like rosiglitazone upregulate ENaC channels, which should make loop diuretics less effective. This study found no such effect.
Practical Takeaways
People with insulin resistance taking rosiglitazone can continue using loop diuretics like furosemide for fluid retention without worrying about reduced effectiveness.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Researchers tested if a diabetes drug called rosiglitazone makes water pills less effective at removing salt and water. They gave 12 people with insulin resistance either the drug or a placebo for 9 weeks. They checked how well the water pills worked. The drug didn't change how the water pills worked.
Surprising Findings
Rosiglitazone didn't reduce furosemide's effectiveness despite previous theories
Earlier research suggested TZDs like rosiglitazone upregulate ENaC channels, which should make loop diuretics less effective. This study found no such effect.
Practical Takeaways
People with insulin resistance taking rosiglitazone can continue using loop diuretics like furosemide for fluid retention without worrying about reduced effectiveness.
Publication
Journal
Clinical pharmacology and therapeutics
Year
2011
Authors
Rennings AJ, Russel FG, Li Y, Deen PM, Masereeuw R, Tack CJ, Smits P
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Claims (6)
Insulin resistance results in chronically elevated insulin levels, causing the kidneys to continuously retain sodium due to persistent hormonal signaling.
Taking rosiglitazone for 9 weeks doesn't make the diuretic medicine furosemide less effective at removing salt from the body in people with insulin resistance.
Rosiglitazone doesn't change how furosemide works at different doses in people with insulin resistance.
Taking rosiglitazone doesn't affect how well amiloride (another diuretic) removes salt from the body in insulin-resistant people.
Rosiglitazone doesn't increase the amount of a specific sodium channel protein in urine of insulin-resistant people.