Rosiglitazone doesn't increase the amount of a specific sodium channel protein in urine of insulin-resistant people.

Evidence Quality Assessment

Claim Status

overstated

Study Design Support

Design cannot support claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The abstract uses causal language ('changed'), but the study design is a cohort study without confirmed RCT details, so causation cannot be established; the claim should use association language.

Evidence from Studies

Supporting (1)

31

Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study

Randomized Controlled Trial

Human

2011 Apr

Contradicting (0)

0

No contradicting evidence found

Source Study

Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study

Score: 31

DOI: 10.1038/clpt.2010.360

Similar Assertions

Rosiglitazone doesn't change how furosemide works at different doses in people with insulin resistance.

31

0

87%

Fluid buildup caused by TZDs can still be treated with loop diuretics like furosemide in people with insulin resistance.

31

0

84%

Taking rosiglitazone for 9 weeks doesn't make the diuretic medicine furosemide less effective at removing salt from the body in people with insulin resistance.

31

0

82%

Taking rosiglitazone doesn't affect how well amiloride (another diuretic) removes salt from the body in insulin-resistant people.

31

0

82%