For every point increase in HOMA-IR score (a measure of insulin resistance), Korean adults with healthy kidneys have a 13% higher chance of developing kidney disease over 11 years.
Scientific Claim
Each unit increase in homeostasis model assessment-insulin resistance (HOMA-IR) is associated with a 13% higher risk of developing chronic kidney disease in Korean adults with normal kidney function at baseline.
Original Statement
“After adjustment for age, sex, history of HTN, BMI, total cholesterol, alcohol drinking status, smoking status, and baseline eGFR, the risk of incident CKD increased with higher HOMA-IR levels (HR, 1.13; 95% CI, 1.05–1.22; p = 0.001).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design supports correlational claims, and the language correctly uses 'associated with' without implying causation. The hazard ratio and confidence interval are accurately reported.