Analysis Version
v1
History
Back to Study: Insulin resistance is associated with incident chr...
correlational
Analysis v1
59
Pro
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Against

In Korean adults with healthy kidneys, the link between insulin resistance and kidney disease risk doesn't change based on age, gender, high blood pressure, or obesity status.

Scientific Claim

The association between insulin resistance and chronic kidney disease risk remains consistent across subgroups of age, sex, hypertension status, and obesity in Korean adults with normal kidney function.

Original Statement

“Cox regression analysis regarding the association between HOMA-IR level and the risk of incident CKD revealed that p for interaction was >0.05 for all subgroups, suggesting that the association of high HOMA-IR level with increased risk of incident CKD is not modified by these factors.”

From study:Insulin resistance is associated with incident chronic kidney disease in population with normal renal function

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design supports correlational claims about subgroup consistency. The language correctly describes the lack of interaction without implying causation.

Evidence from Studies

Supporting (1)

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59

Insulin resistance is associated with incident chronic kidney disease in population with normal renal function

Cohort Study
Human
2025 May

Contradicting (0)

0
No contradicting evidence found

Source Study

Insulin resistance is associated with incident chronic kidney disease in population with normal renal function

Score: 59
DOI: 10.23876/j.krcp.22.298

Similar Assertions

For every point increase in HOMA-IR score (a measure of insulin resistance), Korean adults with healthy kidneys have a 13% higher chance of developing kidney disease over 11 years.

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79%

Korean adults with healthy kidneys who have high insulin resistance (HOMA-IR >1.9) are 40% more likely to develop kidney disease over 11 years compared to those with normal insulin resistance.

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78%

Insulin resistance causes chronically elevated insulin, leading to sodium retention by kidneys and reduced nitric oxide production, resulting in increased vascular resistance and blood pressure.

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70%