High insulin levels may harm kidneys even before problems start
Insulin resistance is associated with incident chronic kidney disease in population with normal renal function
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Insulin resistance increases CKD risk even in people without hypertension or obesity
Many assume only those with existing conditions like high blood pressure or obesity are at risk, but this shows insulin resistance alone is a major factor regardless of other health issues.
Practical Takeaways
Get tested for HOMA-IR or QUICKI during routine checkups—even if your kidneys seem healthy.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Insulin resistance increases CKD risk even in people without hypertension or obesity
Many assume only those with existing conditions like high blood pressure or obesity are at risk, but this shows insulin resistance alone is a major factor regardless of other health issues.
Practical Takeaways
Get tested for HOMA-IR or QUICKI during routine checkups—even if your kidneys seem healthy.
Publication
Journal
Kidney Research and Clinical Practice
Year
2023
Authors
S. Song, Young Jin Goo, Tae Ryom Oh, Sang Heon Suh, H. Choi, C. Kim, S. Ma, S. Kim, E. Bae
Related Content
Claims (6)
Insulin resistance results in chronically elevated insulin levels, causing the kidneys to continuously retain sodium due to persistent hormonal signaling.
Korean adults with healthy kidneys who have high insulin resistance (HOMA-IR >1.9) are 40% more likely to develop kidney disease over 11 years compared to those with normal insulin resistance.
For every point increase in HOMA-IR score (a measure of insulin resistance), Korean adults with healthy kidneys have a 13% higher chance of developing kidney disease over 11 years.
Korean adults with healthy kidneys who have lower QUICKI scores (indicating worse insulin sensitivity) have a 38% higher chance of developing kidney disease over 11 years compared to those with higher QUICKI scores.
Korean adults with healthy kidneys who have higher leptin-to-adiponectin ratios (a marker of metabolic dysfunction) are 23% more likely to develop kidney disease over 11 years.