For people with HIV and belly fat who responded to tesamorelin by losing belly fat, taking the drug for 26 weeks made their trunk muscles denser by 1.56 to 4.86 units compared to those who didn't take it.

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Evidence from Studies

Supporting (1)

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The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV

Randomized Controlled Trial

Human

2019

In people with HIV and belly fat who lost a lot of that fat from the drug tesamorelin, their trunk muscles got stronger and denser—like muscle getting more packed and less fatty—compared to those who got a placebo.

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No contradicting evidence found

Source Study

The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV

Score: 60

DOI: 10.14283/jfa.2018.45

Similar Assertions

For HIV patients with belly fat who responded to this drug, taking tesamorelin for 6 months made their trunk muscles less fatty and more dense, like turning soft muscle into firmer muscle.

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For people with HIV and belly fat who responded to tesamorelin, the drug helped increase muscle density in their trunk muscles by 1.56 to 4.86 units compared to those who didn't take it.

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For HIV patients with belly fat who responded to tesamorelin, the drug was linked to better muscle density in four trunk muscles, with improvements between 1.56 and 4.86 units compared to placebo after 26 weeks.

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HIV patients with belly fat who responded to tesamorelin had more lean muscle mass in all four trunk muscles, with increases between 0.64 and 1.08 cm² compared to placebo after 26 weeks.

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HIV patients with belly fat who responded to tesamorelin saw better lean muscle quality in their abdominal and rectus muscles, with improvements of 1.39 and 1.78 units respectively compared to placebo after 26 weeks.

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