Higher adherence to sulforaphane supplements is linked to a measurable decrease in the Ki-67 marker in bronchial tissue, which indicates reduced cell proliferation.
Mechanism
Synthesis from 1 study
Sulforaphane turns on a cellular cleanup system that removes harmful chemicals from airway cells. This stops the cells from growing too fast, which is why the marker of abnormal cell growth goes down when people take the supplement regularly.
Most probable mechanism
Sulforaphane enters cells in the airways and turns on a protective system that cleans up harmful chemicals and reduces damage to DNA. This causes the cells to stop multiplying abnormally, which lowers the number of cells showing signs of uncontrolled growth.
Sulforaphane is absorbed from the digestive tract and reaches bronchial epithelial cells
Sulforaphane modifies specific cysteine residues on Keap1, preventing it from targeting Nrf2 for degradation
Nrf2 accumulates and moves into the nucleus, where it binds to antioxidant response elements and activates transcription of detoxification and cytoprotective genes
Increased expression of detoxification enzymes reduces oxidative stress and DNA damage caused by tobacco carcinogens in bronchial epithelial cells
Reduced DNA damage and oxidative stress suppress proliferative signaling pathways, leading to decreased expression of the Ki-67 proliferation marker
Evidence from Studies
Supporting (1)
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