Can a broccoli compound slow lung cell overgrowth in ex-smokers?
Abstract 749: Randomized placebo-controlled phase II clinical trial on oral supplementation of sulforaphane for 12 months that reduced bronchial Ki-67 index in former smokers at high risk for lung cancer
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Scientists gave ex-smokers a broccoli-derived supplement daily for a year to see if it could calm down overactive lung cells that might lead to cancer.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 561 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave ex-smokers a broccoli-derived supplement daily for a year to see if it could calm down overactive lung cells that might lead to cancer.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 561 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
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Claims (6)
Former smokers who took 120 micromoles of sulforaphane daily for 12 months showed a 46% reduction in high-density Ki-67 staining in bronchial tissue, while those who took a placebo showed a 99% increase.
Taking 120 micromoles of sulforaphane daily for a year does not change levels of Caspase-3 or TUNEL markers in the bronchial tissue of former smokers.
Higher adherence to sulforaphane supplements is linked to a measurable decrease in the Ki-67 marker in bronchial tissue, which indicates reduced cell proliferation.
Taking 120 micromoles of sulforaphane daily for one year reduced the Ki-67 proliferation index by 24% in bronchial tissue of former smokers with a 30 pack-year smoking history.
Taking 120 micromoles of sulforaphane daily for one year did not lead to severe side effects in former heavy smokers.