The Claim

High-density Ki-67 staining (3+) in bronchial tissue decreased by 46% in former smokers taking 120 μmol of sulforaphane daily for 12 months, compared to a 99% increase in the placebo group, indicating a targeted suppression of highly proliferative cell populations.

Source: Abstract 749: Randomized placebo-controlled phase II clinical trial on oral supplementation of sulforaphane for 12 months that reduced bronchial Ki-67 index in former smokers at high risk for lung cancer

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
61score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Quantitative
1 study reviewed
In plain English

Former smokers who took 120 micromoles of sulforaphane daily for 12 months showed a 46% reduction in high-density Ki-67 staining in bronchial tissue, while those who took a placebo showed a 99% increase.

See the scientific wording

High-density Ki-67 staining (3+) in bronchial tissue decreased by 46% in former smokers taking 120 μmol of sulforaphane daily for 12 months, compared to a 99% increase in the placebo group, indicating a targeted suppression of highly proliferative cell populations.

Why this might work

Sulforaphane enters cells in the airways and turns on a defense system that cleans up harmful chemicals and repairs damaged DNA. This stops the cells from dividing too fast, which reduces the number of cells showing signs of rapid growth.

Supported mechanismbased on 1 study

What the research says

1 study

  1. Study: Abstract 749: Randomized placebo-controlled phase II clinical trial on oral supplementation of sulforaphane for 12 months that reduced bronchial Ki-67 index in former smokers at high risk for lung cancer

    In former heavy smokers, taking sulforaphane daily for a year cut down the number of super-fast-dividing cells in the airways, while those taking a placebo saw those cells multiply even more. This suggests sulforaphane may help prevent lung cancer by slowing down dangerous cell growth.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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