Giving animals extra Klotho protein seems to help their cells stay younger and their organs work better, especially when they have kidney problems or are getting older — so it might one day help people too.

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Evidence from Studies

Supporting (1)

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Phosphate and Cellular Senescence.

Narrative Review

2022

The study says that when Klotho protein is low, cells age faster and harm organs like the kidneys—but adding back Klotho can help slow this damage, just like the claim says.

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Phosphate and Cellular Senescence.

Score: 1

DOI: 10.1007/978-3-030-91623-7_7

Similar Assertions

When there's not enough of a protein called Klotho, cells age faster—and eating too much phosphate (a mineral found in processed foods) lowers Klotho in animals, which might be why phosphate makes aging worse.

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Mice missing the KDM6A gene in their kidneys show signs of faster aging, like higher levels of certain proteins linked to aging.

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