When there's not enough of a protein called Klotho, cells age faster—and eating too much phosphate (a mineral found in processed foods) lowers Klotho in animals, which might be why phosphate makes aging worse.

1

Pro

0

Against

Evidence from Studies

Supporting (1)

1

Community contributions welcome

1

Phosphate and Cellular Senescence.

Narrative Review

2022

Too much phosphate in the body lowers a protective protein called Klotho, which makes cells age faster — and the study shows that fixing low Klotho can slow this down.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Phosphate and Cellular Senescence.

Score: 1

DOI: 10.1007/978-3-030-91623-7_7

Similar Assertions

Giving animals extra Klotho protein seems to help their cells stay younger and their organs work better, especially when they have kidney problems or are getting older — so it might one day help people too.

1

0

82%

If young men eat a lot of phosphate for five days, their body makes less of a special hormone called Klotho that helps keep bones and kidneys healthy — so too much phosphate might quiet down this helpful hormone.

54

0

75%

When there’s too much phosphate in the fluid around certain cells in the body, those cells start showing signs of aging faster—like they’re getting old and worn out. This has been seen in lab tests and animal studies.

1

0

75%

Mice missing the KDM6A gene in their kidneys show signs of faster aging, like higher levels of certain proteins linked to aging.

6

0

71%