Giving rats a traditional herbal supplement called shilajit for 4 days before radiation exposure helped protect their ovaries by reducing cell death signals that normally get turned on by radiation.
Scientific Claim
Shilajit administration at a dosage of 25 mg/kg/day for 4 days reduced radiation-induced apoptosis in rat ovaries by decreasing expression of p53, Bax, and caspase 3 proteins, which are key mediators of the apoptotic pathway, suggesting potential protective effects against radiation damage to ovarian tissue.
Source Excerpt
“In radiation + shilajit group, p53, Bax and caspase 3 expression was less intense than that in the radiation only group follicles.”
Evidence from Studies
Supporting Studies
Evaluation of preventive effect of shilajit on radiation-induced apoptosis on ovaries
The study compared ovarian tissue from rats exposed to radiation with and without shilajit pretreatment. Immunohistopathological analysis showed reduced expression of apoptotic markers (p53, Bax, caspase 3) in the shilajit-treated group, indicating decreased activation of the apoptotic pathway.