When rats were given shilajit before radiation treatment, their ovaries showed lower levels of proteins that trigger cell death, suggesting shilajit might help prevent radiation from killing egg cells.
Scientific Claim
Shilajit administration at 25 mg/kg/day for 4 days before radiation exposure was associated with reduced expression of apoptotic markers (p53, Bax, and caspase 3) in rat ovarian follicles, suggesting it may block apoptotic pathways activated by radiation.
Source Excerpt
“Shilajit decreased the expression of p53, Bax, and caspase 3, thereby blocking the apoptotic pathways.”
Evidence from Studies
Supporting Studies
Evaluation of preventive effect of shilajit on radiation-induced apoptosis on ovaries
The study used immunohistopathological analysis to measure expression of key apoptotic proteins. The radiation + shilajit group showed less intense expression of p53, Bax, and caspase 3 compared to the radiation-only group, indicating reduced activation of the apoptotic cascade.