When the liver is overloaded, it can't process fat properly, making it harder to lose weight. NAC helps the liver work better so fat can be processed normally.
Scientific Claim
Hepatic glutathione depletion impairs fat metabolism and insulin signaling, leading to inefficient fat processing and blood sugar dysregulation; NAC supplementation restores hepatic glutathione levels, improving liver function and fat metabolism.
Original Statement
“Okay. Okay. So when glutathon runs low, fat handling suffers, takes a back seat. Insulin signaling becomes sloppy. Energy becomes inconsistent. So you have to think of the liver like almost almost an air traffic controller. Okay? It's like when it's overwhelmed, fat just backs up into circulation. Planes can't land, things get jacked up, blood sugar control worsens, fat loss stalls. NAC helps clear the traffic so that the planes can land and complete the job. And that's why improving liver health often improves fat loss indirectly without changing calories. Okay, still got the same amount of planes flying around. They're just able to land.”
Context Details
Domain
pharmacology
Population
animal
Subject
hepatic glutathione depletion
Action
impairs
Target
fat metabolism and insulin signaling
Intervention Details
Evidence from Studies
Supporting (2)
N‐acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders