Antioxidant helps mouse hearts with fibrosis but not pumping power
N‐acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists tested if an antioxidant called NAC could help mouse hearts with heart failure caused by a specific gene problem. They gave NAC to some mice and saline to others for 8 weeks.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 516 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists tested if an antioxidant called NAC could help mouse hearts with heart failure caused by a specific gene problem. They gave NAC to some mice and saline to others for 8 weeks.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 516 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Giam B, Chu PY, Kuruppu S, Smith AI, Horlock D, Kiriazis H, Du XJ, Kaye DM, Rajapakse NW
Related Content
Claims (10)
Hepatic glutathione depletion impairs fat metabolism and insulin signaling, leading to inefficient fat processing and blood sugar dysregulation; NAC supplementation restores hepatic glutathione levels, improving liver function and fat metabolism.
Giving the antioxidant NAC to mice with heart failure didn't help their heart's pumping ability improve, even though it reduced some scarring.
Giving mice a specific antioxidant called NAC for 8 weeks made the scarring in their heart blood vessels and tissue about 40-57% less than in mice that didn't get the antioxidant.
The antioxidant NAC made the heart cells in mice with heart failure produce about 42% less of a marker that shows oxidative stress.
Mice with a specific genetic modification that causes heart failure had more than double the scarring in their heart blood vessels and tissue compared to normal mice.