Giving the antioxidant NAC to mice with heart failure didn't help their heart's pumping ability improve, even though it reduced some scarring.

Pro

Against

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N‐acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure

Randomized Controlled Trial

Animal

2016 Apr

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No contradicting evidence found

The antioxidant NAC didn't change the size of the heart muscle in mice with heart failure.

91%

The antioxidant NAC didn't change the blood pressure in mice with heart failure, even though it reduced heart scarring.

90%

The antioxidant NAC didn't change the levels of two heart stress markers in mice with heart failure.

86%

The antioxidant NAC made the heart cells in mice with heart failure produce about 30-40% less of the proteins that form scar tissue.

83%

The antioxidant NAC made the heart cells in mice with heart failure produce about 42% less of a marker that shows oxidative stress.

81%