The antioxidant NAC didn't change the blood pressure in mice with heart failure, even though it reduced heart scarring.
Scientific Claim
N-acetylcysteine treatment did not significantly affect blood pressure measurements in a mouse model of heart failure with cardiac-specific MST-1 overexpression.
Original Statement
“Mean arterial pressure, systolic arterial pressure, and diastolic arterial pressure were less in MST‐1 mice compared to WT mice (P ≤ 0.007; Figs. 3, 5). In both genotypes, NAC had minimal effect on blood pressure (P ≥ 0.52; Figs. 3, 5).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim correctly states the lack of significant effect on blood pressure in this specific mouse model without overgeneralizing.
More Accurate Statement
“N-acetylcysteine treatment was not associated with significant changes in blood pressure measurements in a mouse model of heart failure with cardiac-specific MST-1 overexpression.”
Evidence from Studies
Supporting (1)
N‐acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure