The antioxidant NAC made the heart cells in mice with heart failure produce about 42% less of a marker that shows oxidative stress.
Scientific Claim
N-acetylcysteine reduced cardiac oxidative stress by 42% in a mouse model of heart failure with cardiac-specific MST-1 overexpression, as measured by dihydroethidium staining.
Original Statement
“Cardiac oxidative stress was 119% greater in MST‐1 than in wild type (P < 0.001) and N‐acetylcysteine attenuated oxidative stress in MST‐1 by 42% (P = 0.005).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim correctly specifies the animal model and measurement method. It doesn't overstate to humans or imply causation beyond the study design.
More Accurate Statement
“N-acetylcysteine was associated with a 42% reduction in cardiac oxidative stress in a mouse model of heart failure with cardiac-specific MST-1 overexpression, as measured by dihydroethidium staining.”
Evidence from Studies
Supporting (1)
N‐acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure