The antioxidant NAC didn't change the levels of two heart stress markers in mice with heart failure.
Scientific Claim
N-acetylcysteine treatment did not significantly affect cardiac BNP and β-MHC expression in a mouse model of heart failure with cardiac-specific MST-1 overexpression.
Original Statement
“In both genotypes, NAC treatment had minimal effect on cardiac BNP and β-MHC expression (P ≥ 0.56; Fig. 9).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim correctly states the lack of significant effect on cardiac markers in this specific mouse model without overgeneralizing.
More Accurate Statement
“N-acetylcysteine treatment was not associated with significant changes in cardiac BNP and β-MHC expression in a mouse model of heart failure with cardiac-specific MST-1 overexpression.”
Evidence from Studies
Supporting (1)
N‐acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure