Mice with a specific genetic modification that causes heart failure had more than double the scarring in their heart blood vessels and tissue compared to normal mice.
Scientific Claim
Cardiac-specific MST-1 overexpression in mice resulted in 114% greater perivascular fibrosis and 209% greater interstitial fibrosis compared to wild-type mice.
Original Statement
“Cardiac perivascular and interstitial fibrosis were greater by 114% and 209%, respectively, in MST‐1 compared to wild type (P ≤ 0.001).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim correctly describes the comparison between mouse groups without implying causation beyond the study design. It specifies the model and measurement method.
More Accurate Statement
“Cardiac-specific MST-1 overexpression in mice was associated with 114% greater perivascular fibrosis and 209% greater interstitial fibrosis compared to wild-type mice.”
Evidence from Studies
Supporting (1)
N‐acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure